2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-119521S1
    Mexiletine-d6 1330267-50-9 98%
    Mexiletine-d6 (KOE-1173-d6) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research.
    Mexiletine-d6
  • HY-119695AR
    Simvastatin acid ammonium (Standard) 139893-43-9 98%
    Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
    Simvastatin acid ammonium (Standard)
  • HY-122537AR
    Arotinolol (Standard) 68377-92-4 98%
    Arotinolol (Standard) is the analytical standard of Arotinolol. This product is intended for research and analytical applications. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.
    Arotinolol (Standard)
  • HY-131987S1
    Ethacizine-d4 98%
    Ethacizine-d4 is the deuterium labeled Ethacizine (HY-131987). Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels.
    Ethacizine-d4
  • HY-15407AS2
    Sacubitril-d5 hemicalcium 98%
    Sacubitril-d5 (AHU-377-d5) hemicalcium is deuterium-labeled Sacubitril hemicalcium (HY-15407A).
    Sacubitril-d5 hemicalcium
  • HY-17503AS1
    Metoprolol-d6 succinate 98%
    Metoprolol-d6 (succinate) is deuterium labeled Metoprolol (succinate). Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties.
    Metoprolol-d6 succinate
  • HY-B0203BS1
    (rac)-Nebivolol-d4 1219407-55-2 98%
    (rac)-Nebivolol-d4 is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].
    (rac)-Nebivolol-d4
  • HY-B0432AS2
    Propafenone-d5 hydrochloride 1346605-05-7 98%
    Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone-d5 hydrochloride
  • HY-B0432AS3
    Propafenone-d5 hydrochloride(Ethyl) 1398066-02-8 98%
    Propafenone-d5 Ethyl (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79）hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone-d5 hydrochloride(Ethyl)
  • HY-B0477AS1
    Quinapril-d5 hydrochloride 1356020-03-5 98%
    Quinapril-d5 hydrochloride (CI-906-d5) is the deuterium labeled Quinapril hydrochloride. Quinapril hydrochloride (CI-906) is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications.
    Quinapril-d5 hydrochloride
  • HY-B0477AS2
    Quinapril-d4 98%
    Quinapril-d4 (CI-906-d4) is deuterium labeled Quinapril. Quinapril is a potent, orally active, non-peptide and nonsulfhydryl inhibitor of angiotensin-converting enzyme (ACE). Quinapril specifically interrupts the conversion of angiotensin I to angiotensin II in both plasma and tissue. Quinapril is enzymatically hydrolyzed to a pharmacologically active diacid form quinaprilat. Quinapril is efficacious in hypertensive models.
    Quinapril-d4
  • HY-N0830S22
    Palmitic acid-13C-1 158045-29-5 98%
    Palmitic acid-13C-1 is the 13C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.
    Palmitic acid-13C-1
  • HY-N2037AS1
    Higenamine-d4-1 hydrochloride 98%
    Higenamine-d4-1 (Norcoclaurine-d4-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases.
    Higenamine-d4-1 hydrochloride
  • HY-W001940R
    DL-m-Tyrosine (Standard) 775-06-4 98%
    DL-m-Tyrosine (Standard) is the analytical standard of DL-m-Tyrosine (HY-W001940). This product is intended for research and analytical applications. DL-m-Tyrosine is a non-protein amino acid. DL-m-Tyrosine inhibits microbial growth and spore formation. DL-m-Tyrosine also inhibits root growth in various plants, such as lettuce and Arabidopsis. DL-m-Tyrosine, when used in combination with Carbidopa (HY-B0311), has a potent antihypertensive effect. DL-m-Tyrosine can be used in research on biopesticide design.
    DL-m-Tyrosine (Standard)
  • HY-W001940S
    DL-m-Tyrosine-d3 98%
    DL-m-Tyrosine-d3 is the deuterium labeled DL-m-Tyrosine (HY-W001940). DL-m-Tyrosine is a non-protein amino acid. DL-m-Tyrosine inhibits microbial growth and spore formation. DL-m-Tyrosine also inhibits root growth in various plants, such as lettuce and Arabidopsis. DL-m-Tyrosine, when used in combination with Carbidopa (HY-B0311), has a potent antihypertensive effect. DL-m-Tyrosine can be used in research on biopesticide design.
    DL-m-Tyrosine-d3
  • HY-W007347R
    1,2-Cyclohexanedione (Standard) 765-87-7 98%
    1,2-Cyclohexanedione is an endogenous metabolite.
    1,2-Cyclohexanedione (Standard)
  • HY-W008125S
    Acetobromo-a-D-glucuronic acid-13C6 methyl ester 98%
    Acetobromo-a-D-glucuronic acid-13C6 methyl ester (Methyl acetobromo-α-D-glucuronate-13C6 methyl ester) is 13C labeled Acetobromo-α-D-glucuronic acid methyl ester, 98% (HY-W008125). Acetobromo-α-D-glucuronic acid methyl ester, 98% is an intermediate. Acetobromo-α-D-glucuronic acid methyl ester, 98% can be used to synthesize HMR1098-S-Glucuronide Methyl Ester. HMR1098 is a novel KATP blocker that is metabolized to S-glucuronide in rat and dog bile. Acetobromo-α-D-glucuronic acid methyl ester, 98% can be used in the research of sudden cardiac death.
    Acetobromo-a-D-glucuronic acid-13C6 methyl ester
  • HY-W008393R
    (-)-Corey lactone diol (Standard) 32233-40-2
    (-)-Corey lactone diol (Standard) is an analytical standard for (-)-Corey lactone diol (HY-W0088393). This product is intended for research and analytical applications. (-)-Corey lactone diol is the reduced form of Corey aldehyde. (-)-Corey lactone diol can be used as a pharmaceutical intermediate in the synthesis of Beraprost (HY-13569A).
    (-)-Corey lactone diol (Standard)
  • HY-W009749R
    L-Cystathionine (Standard) 56-88-2 98%
    L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.
    L-Cystathionine (Standard)
  • HY-W010144R
    Phenidone (Standard) 92-43-3 98%
    Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Phenidone is used as a photographic developer.
    Phenidone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity